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Fluorouracil 5% & 1% Cream – Product Information
Fluorouracil Cream (Flonida Cream) is available in 1% and 5 % strength. Fluorouracil Cream contains fluorouracil for topical dermatologic use.
Fluorouracil the active pharmaceutical ingredient in Fluorouracil cream stops the growth of abnormal skin cells. Fluorouracil Cream is used to treat various skin conditions such as keratosis, superficial basal cell carcinoma, psoriasis and genital warts.
Name of Drug
Fluorouracil cream. Fluorouracil cream are more well known as Generic Carac®. Fluorouracil Cream is also referred to as Flonida Cream and Fluorouracil topical.
Manufacturer of Fluorouracil Cream (Flonida Cream)
Aurochem Laboratories (I) Private Limited
Marketed by and distributed by Menarini Italy
Active Pharmaceutical Ingredient in Fluorouracil Cream (Flonida Cream)
The active pharmaceutical ingredient present in Flonida Cream (Flonida Cream) is fluorouracil.
Uses of Fluorouracil Cream
Fluorouracil Cream (Flonida Cream) is used for the topical treatment of the below mentioned indications:
- solar keratosis of the face and anterior scalp
- actinic keratosis
- superficial basal cell carcinoma
- Bowen''s disease (a type of skin cancer)
Fluorouracil Cream is also is used to treat some noncancerous conditions in which cells are dividing rapidly, including:
- genital warts
- porokeratosis (an unusual inherited skin condition causing dry patches on the arms and legs)
Fluorouracil Cream works best on the face and scalp and is less effective on other areas of the body. It also destroys sun-damaged skin cells making the skin smoother and more youthful-appearing.
Fluorouracil Cream (Flonida Cream) - Dosage and Administration
Fluorouracil cream should be applied once a day to the skin in the affected area, using enough to cover the entire area with a thin film. Usual Adult Dose for Skin Cancer:
Superficial basal cell carcinoma:
Apply 5% cream to lesions twice daily with gloves or nonmetal applicators.
Treatment should continue for at least 3 to 6 weeks, and may be required for as long as 10 to 12 weeks to resolve the lesions.
Usual Adult Dose for Keratosis:
Apply to the affected area once a day.
Actinic or solar keratosis:
Apply to the affected area twice daily with gloves or nonmetallic applicator, using sufficient amount to cover the lesions.
The usual duration of therapy is 2 to 4 weeks, until the inflammatory response reaches the erosion state, at which time treatment is discontinued. Lesions may not heal completely for 1 to 2 months after fluorouracil therapy has been discontinued.
Solar keratoses which do not respond to treatment should be biopsied to confirm the diagnosis. Do not treat children with Fluorouracil Cream.
Drug Class and Mechanism
Fluorouracil Cream belongs to the class of antineoplastic agents, it is an antimetabolite.
Fluorouracil Cream (Flonida Cream, Topical fluorouracil, Efudex, Fluoroplex) is a medication that is used to treat conditions of the skin in which there is rapid multiplication (division) of cells, for example, skin cancer. In order to multiply or divide, cells must produce DNA for each new cell. The DNA is critical since it is the genetic material that directs the activity of all cells. Production of DNA depends on the production of RNA which serves as a messenger during the production of DNA. Fluorouracil Cream prevents the formation of RNA which, in turn, prevents the formation of DNA. As a result, cells cannot multiply. With continued treatment, the remaining cells also die.
Apply the missed dose of Fluorouracil Cream as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule. Ask your doctor about what you should do if you miss a dose. DO NOT double a dose under any circumstances.
Storage Instructions for Fluorouracil Cream (Fluorouracil)
Store Fluorouracil Cream at room temperature away from moisture and heat. Throw away unused medication. Keep Fluorouracil Cream out of the reach of children and pets.
Warnings and Precautions when using Fluorouracil Cream
Before using Fluorouracil Cream, please inform your doctor all the medicines that you take including no prescription medications, over the counter medicines and herbal remedies. Do not use Fluorouracil Cream, if you are pregnant or breastfeeding. Fluorouracil Cream may cause Fetal harm if administered to a pregnant woman. Fluorouracil is contraindicated in women who are or may become pregnamt. Avoid pregnancy for 1 month after you stop treatment.
Fluorouracil is contraindicated in patients with known hypersensitivity to Fluorouracil or any of its inactive components. The potential for a delayed hypersensitivity reaction to fluorouracil exists. Patients should discontinue therapy with Fluorouracil Cream if symptoms of DPD enzyme deficiency develop. Rarely, unexpected, systemic toxicity (e.g. stomatitis, diarrhea, neutropenia, and neurotoxicity) associated with parenteral administration of Fluorouracil Cream ( Fluorouracil Cream) has been attributed to deficiency of dihydropyrimidine dehydrogenase "DPD" activity. Do not treat children with Fluorouracil Cream.
Your skin will be more sensitive to sunburn when you use Fluorouracil Cream. Use a sunscreen with a minimum sun protection factor (SPF) 15 while your skin is exposed to the sun or artificial UV rays.
Fluorouracil Cream may cause lightning of your skin.
Do not use Fluorouracil Cream, if you have dihydropyrimidine dehydrogenase (DPD) enzyme deficiency.
Avoid using Fluorouracil Cream on your eyelids and in your eyes, nose and mouth.
Possible Side Effects of Fluorouracil Cream
Serious side effects are not likely to occur. Stop using Fluorouracil Cream and seek emergency medical attention if you experience an allergic reaction (shortness of breath; closing of your throat; swelling of your lips, face, or tongue; or hives).
Fluorouracil Cream may cause skin irritation, dryness, scaling or peeling (exfoliation), rash, and other local reactions. Eye irritation has also been reported. If these side effects are excessive or worsen with continued treatment, contact your doctor.
Buy Fluorouracil cream (Flonida Cream) 1% and 5 % at the Best Price Online
You can buy Fluorouracil 1% and 5 % Cream online from the Swiss Pharmacy. Flonida Cream is available in tubes of 10 g. The price of 10 g 1% Tubes is only $7.5 per unit if you place an order for 10 tubes.
This Product was added to our catalogue on Tuesday, 06. September 2011.