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Dapoxetine Tablets


Dapoxetine Tablets
 

Dapoxetine Tablets

  Product: Dapoxetine Tablets
excl.


Quantity:

Package

10 pills 60mg 19.00 USD unit price: 1.90 $
20 pills 60mg 36.00 USD unit price: 1.80 $
30 pills 60mg 52.00 USD unit price: 1.73 $
60 pills 60mg 102.00 USD unit price: 1.70 $
90 pills 60mg 148.00 USD unit price: 1.64 $
120 pills 60mg 192.00 USD unit price: 1.60 $
180 pills 60mg 279.00 USD unit price: 1.55 $
240 pills 60mg 360.00 USD unit price: 1.50 $



Generic Dapoxetine Tablets (Everlast Tablets) - Product Information

Everlast tablets (Generic Dapoxetine Hydrochloride) is a short-acting selective serotonin reuptake inhibitor (SSRI) used for the treatment of premature ejaculation in men aged 18 to 64 years.
Everlast should only be prescribed to patients who meet all the following criteria: An intravaginal ejaculatory latency time (IELT) of less than two minutes; and persistent or recurrent ejaculation with minimal sexual stimulation before, on, or shortly after penetration and before the patient wishes; and marked personal distress or interpersonal difficulty as a consequence of PE; and poor control over ejaculation; s well as a history of premature ejaculation in the majority of intercourse attempts over the prior 6 months.
Dapoxetine Hydrochloride is only indicated in men with Premature Ejaculation who meet all the criteria.
Everlast tablets (60 mg) should not be prescribed to men who have not been diagnosed with Premature Ejaculation.
You can buy Generic Dapoxetine 60 mg (Everlast Tablets) at a cheap price online for only $1.50 a pill.

We also have in stock Alphagra Superb, a combination of Sildenafil Citrate and Dapoxetine Hydrochloride which helps adult men to achieve and maintain erections as well as treat premature ejaculation at the same time.

Name of Drug

Dapoxetine Hydrochloride 60 mg : We supply Everlast 60 mg manufactured by Alpha-Pharma Healthcare.
Sometimes Dapoxetine is also referred to as Poxitin.

Manufacturer of Everlast Tablets

Alpha Pharma Healthcare Private limited, India.
Website: www.alpha-pharma.com

Everlast   60 mg  tablets manufactured by  Alpha-Pharma Healthcare Pvt. Ltd.



Active Pharmaceutical Ingredient in Everlast Tablets

The active pharmaceutical ingredient present in Everlast Tablets is Dapoxetine Hydrochloride. Each Everlast film coated tablet contains 60 mg of Dapoxetine base (as hydrochloride).

Uses of Everlast Tablets (Generic Dapoxetine Hydrochloride)

Dapoxetine Hydrochloride (Everlast tablets) is the only drug with regulatory approval for the indication of premature ejaculation (PE).
Premature ejaculation (PE) is a common male sexual disorder which is associated with substantial personal and interpersonal negative psychological consequences. Dapoxetine Tablets are used for the treatment of premature ejaculation in male subjects aged 18 to 64 years who have the following:
i) persistent or recurrent ejaculation with minimal sexual stimulation before, on, or shortly after penetration and before the patient wishes,
ii) marked personal distress or interpersonal difficulty as a consequence of premature ejaculation, and
iii) poor control over ejaculation.

Everlast Tablets - Contraindications

Everlast tablets are contraindicated in patients with known hypersensitivity to Dapoxetine Hydrochloride or any inactive ingredient present in Everlast tablets. Everlast tablets are also contraindicated in patients with significant pathological cardiac conditions. Dapoxetine is contraindicated for concomitant treatment with monoamine oxidase inhibitors (MAOIs), thioridazine, serotonin reuptake inhibitors, selective serotonin reuptake inhibitors (SSRIs) or within 14 days of discontinuing treatment with an MAOI, thioridazine or serotonin reuptake inhibitors, selective serotonin reuptake inhibitors (SSRIs).

Dapoxetine Tablets (Everlast Tablets) - Dosage

It is taken by mouth, in tablet form. Dapoxetine Tablets should be swallowed whole. The recommended starting dose for all patients (men aged 18 to 64 years) is 30 mg, taken as needed approximately 1 to 3 hours prior to sexual activity.
If the individual response to 30 mg is insufficient and the patient has not experienced moderate or severe adverse reactions or prodromal symptoms suggestive of syncope, the dose may be increased to a maximum recommended dose of 60 mg taken as required approximately 1 to 3 hours prior to sexual activity.

The maximum recommended dose is one 60 mg tablets every 24 hours.
It is recommended that the tablet be taken with at least one full glass of water.
Elderly (age 65 years and over): The efficacy and safety of Dapoxetine HCl Tablets have not been established in patients age 65 years and over.

Drug Class and Mechanism

Dapoxetine HCl, the active ingredient present in Dapoxetine Tablets is a short-acting selective serotonin reuptake inhibitor (SSRI) marketed for the treatment of premature ejaculation in men. Delaying male climax is a well-known effect of certain antidepressants. The time to maximal plasma concentration is only 1 hour. The initial elimination half-life is 1.2 hours, and the plasma concentration at 24 hours is < 5% of the maximal concentration. These properties allow for dapoxetine to be delivered as an on-demand preparation. 
Dapoxetine (Generic Dapoxetine)  has the ability to lengthen the time between sexual arousal and climax.
The effect of dapoxetine can last as long as 15 hours.

 

Missed Dose

Take the dose as you need it.

Everlast Tablets - Storage Instructions

Store Everlast Tablets (Generic Dapoxetine Hydrochloride tablets) at room temperature, away from moisture. Keep away from children and pets.

Warnings and Precautions when using Dapoxetine Hydrochloride Tablets (Everlast Tablets)

Before using Dapoxetine Tablets please inform your doctor all the medicines that you take including no prescription medications, over the counter medicines and herbal remedies. Dapoxetine is generally well tolerated.
However, do not drive or operate potentially dangerous machinery after taking Everlast Tablets (Generic Dapoxetine Hydrochloride tablets) because symptoms such as dizziness or lightheadedness may occur.
Dapoxetine tablets should not be prescribed to men who have not been diagnosed with Premature Ejaculation. Safety has not been established and there are no data on the ejaculation-delaying effects in men without Premature Ejaculation.
Recreational drugs with serotonergic activity such as Ketamine, Methylenedioxy-Methamphetamine (MDMA) and lysergic acid diethylamide (LSD) may lead to potentially serious reactions if combined with Everlast tablets.
Combining alcohol with Everlast may increase alcohol-related neurocognitive effects and may also enhance neurocardiogenic adverse events such as syncope, thereby increasing the risk of accidental injury; therefore, patients should be advised to avoid alcohol while taking this medicine.
The number and percentage of subjects with syncope (characterized as loss of consciousness) was greater in Dapoxetine-treated subjects than in those who were treated with placebo. A dose- response relationship for syncope is suggested based on subject incidence across all studies. Subjects with underlying cardiovascular disease were excluded from Phase 3 clinical trials.
The risk of adverse cardiovascular outcomes from syncope (cardiac syncope and syncope from other causes) is increased in patients with underlying structural cardiovascular disease Alteration in cardiac conduction was observed only in preclinical isolated in vitro/ ex vivo models, and not in whole-animal testing. In clinical studies, supraventricular beats and arrhythmias were slightly higher on Dapoxetine.
An orthostatic test should be performed before initiating therapy. In case of a history of documented or suspected orthostatic reaction, treatment with Dapoxetine should be avoided. Caution is advised in all patients concomitantly treated with moderate CYP3A4 inhibitors. Unless the patient is known to be a CYP2D6 extensive metaboliser, caution is advised when used concomitantly with moderate CYP3A4 inhibitors.
Caution is advised in patients taking potent CYP2D6 inhibitors or in patients known to be of CYP2D6 poor metaboliser genotype, as this may increase exposure levels, which may result in a higher incidence and severity of dose dependent adverse events SSRIs have been shown to increase the risk compared to placebo of suicidal thinking and suicidality in short-term studies in children and adolescents with Major Depressive Disorder and other psychiatric disorders.Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24.
Dapoxetine tablets should not be used in patients with a history of mania/hypomania or bipolar disorder and should be discontinued in any patient who develops symptoms of these disorders. Due to the potential of SSRIs to lower the seizure threshold, Everlast (Dapoxetine tablets) should be discontinued in any patient who develops seizures and avoided in patients with unstable epilepsy. Patients with controlled epilepsy should be carefully monitored.
Men with underlying signs and symptoms of depression should be evaluated prior to treatment with Dapoxetine tablets to rule out undiagnosed depressive disorders. Concomitant treatment of Dapoxetine tablets with antidepressants, including SSRIs and SNRIs, is contraindicated.
There have been reports of bleeding abnormalities with SSRIs. Caution is advised in patients taking Dapoxetine tablets, particularly in concomitant use with medicinal products known to affect platelet function.
Dapoxetine is not recommended for use in patients with severe renal impairment and caution is advised in patients with mild or moderate renal impairment.
Abrupt discontinuation of chronically administered SSRIs used to treat chronic depressive disorders has been reported to result in the following symptoms: dysphoric mood, irritability, agitation, dizziness, sensory disturbances. However, a double-blind clinical trial in subjects with PE designed to assess the withdrawal effects of 62 days of daily or as needed dosing with 60 mg PRILIGY showed no evidence of withdrawal syndrome and little evidence of withdrawal symptoms with only a slightly higher incidence of mild or moderate insomnia and dizziness reported in subjects switched to placebo after daily dosing As with other SSRIs, the use of Dapoxetine tablets has been associated with ocular effects such as mydriasis and eye pain. Dapoxetine should be used with caution in patients with raised intraocular pressure or those at risk of angle closure glaucoma.

During Phase 3 studies, Dapoxetine 30 mg tablets were associated with a higher incidence of mood related side effects, such as insomnia (2.2%), anxiety (1.1%) euphoric mood (0.2%), and depression (0.2%) compared to placebo In Phase 3 studies, Dapoxetine 30 mg was associated with a higher incidence of sexual AEs, such as erectile dysfunction (2.3%) and libido decreased (0.5%) compared to placebo (1.6% and 0.3%, respectively).
In Phase 3 studies, Dapoxetine 30 mg was associated with a higher incidence of accidental injuries (2.7%) compared to placebo (1.8%). While some accidents were reported to be related to syncope occurrence, there was no clear correlation between accidental injury adverse events and events of dizziness or changes in alertness associated with Dapoxetine administration. Safety and efficacy of Dapoxetine tablets have not been established in patients age 65 years and over as limited data are available in this population Dapoxetine tablets should not be used in individuals below 18 years of age.

Side Effects of Dapoxetine Hydrochloride Tablets (Everlast Tablets)

The Possible Side effects of Dapoxetine Hydrochloride pills (Everlast and Poxet) are listed below. The very common side effects ( more than 10%) of Dapoxetine Hydrochloride (Everlast tablets) are Dizziness, Headache, Nausea.
The common side effects (More than 1% to less than 10%) of Dapoxetine tablets are Anxiety, Agitation, Restlessness, Insomnia, Abnormal dreams, Libido decreased, Somnolence, Disturbance in attention, Tremor, Paraesthesia, Vision blurred, Tinnitus, Flushing, Sinus congestion, Yawning, Diarrhoea, Vomiting, Constipation, Abdominal pain, Abdominal pain upper, Dyspepsia, Flatulence, Stomach discomfort, Abdominal distension, Dry mouth, Hyperhidrosis, Erectile dysfunction, Fatigue, Irritability and Blood pressure increased.

Everlast Tablets During Pregnancy

Dapoxetine Hydrochloride (Everlast Tablets) is classified by the US FDA as Pregnancy Category C.
Everlast Tablets are not indicated for use by women. Neonates exposed to other SSRIs and SNRIs (serotonin and noradrenaline reuptake inhibitors) late in the third trimester have developed complications requiring prolonged hospitalisation, respiratory support and tube feeding. Such complications can arise immediately upon delivery.
There is no evidence to suggest that Dapoxetine exposure has an effect on a partner's pregnancy based on limited observational data from the clinical trial database.

Buy Generic Dapoxetine 60 mg Tablets Online

You can buy Generic Dapoxetine Hydrochloride Tablets online from the Swiss Pharmacy.     The 60 mg pills (Everlast tablets) are available for only $1.50 each if you place an order for 240 tablets.

  
This Product was added to our catalogue on Saturday, 29. January 2011.

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