Rpigat Tablets (Generic Rivaroxaban Tablets) – Product Information
Rpigat (Generic Rivaroxaban Tablets) treats and prevents the formation of blood clots in your body. This is because Rivaroxaban, the active ingredient in Rpigat tablets, is an anticoagulant which thins your blood and reduces its ability to form clots.
Blood clots can form in the blood vessels of your heart or brain if you are suffering from non-valvular atrial fibrillation or arrhythmia (irregular or very rapid heart rhythm) which can result in heart failure, stroke, or other life-threatening complications related to the heart. If you have had a knee or hip replacement surgery, blood clots can form in the veins of your legs leading to a health condition called Deep Vein Thrombosis (DVT). Blood clots can also travel and lodge themselves in the blood vessels of your lungs causing a condition called Pulmonary Embolism (PE).
If you suffer from arrhythmia, Rpigat tablets will greatly reduce your risk of having a heart attack or a stroke. Rpigat tablets will also prevent the formation of blood clots in your veins or blood vessels if you are suffering from Deep Vein Thrombosis (DVT) or Pulmonary Embolism (PE).
Rpigat tablets are manufactured by Natco Pharma Ltd., India, and are available in the strengths of 10 mg, 15 mg and 20 mg.
We also stock Warfarin tablets (Warf) which helps to prevent blood from excessive clotting or forming harmful clots.
Name of Drug
Rpigat Tablets We supply original Rpigat tablets manufactured by Natco Pharma Limited, India in the strength of 15 mg and 20 mg. 10 mg strength is available with short expiration date.(Please contact regarding the 10 mg strength).
Manufacturer of Rpigat Tablets (Generic Rivaroxaban Tablets)
Natco Pharma Limited
Website: www.natcopharma.co.in
Active Pharmaceutical Ingredient
Rivaroxaban is the active pharmaceutical ingredient in Rpigat tablets. Depending on the strength of the tablet, each Rpigat tablet contains 10 mg, 15 mg or 20 mg of Rivaroxaban.
How do Rpigat tablets (Rivaroxaban) work
Rivaroxaban, the active ingredient in Rpigat tablets, is an anticoagulant. It blocks a blood clotting factor called Xa factor, thus reducing the blood’s ability to clot and preventing toxic blood clots from forming in your blood vessels.
What are Rpigat Tablets (Generic Rivaroxaban) used for?
Rpigat tablets (Generic Rivaroxaban tablets) are used to treat and prevent the formation of blood clots in the blood vessels of your heart and brain. This reduces the risk of a stroke or a heart attack if you suffer from a condition called non-valvular atrial fibrillation.
Rpigat tablets (Rivaroxaban) are also used to treat blood clots that can form in the veins of your legs after a knee or a hip replacement surgery (DVT). Blood clots can also make their way to the blood vessels of your lungs (PE), and Rpigat tablets (Rivaroxaban) help treat those as well. The use of Rpigat tablets (Rivaroxaban) will also prevent these clots from forming again.
Rpigat (Rivaroxaban Tablets) Dosage – How to take Rpigat tablets
You should take Rpigat tablets (Rivaroxaban) in the dose prescribed by your doctor and for the duration recommended by your doctor. The tablets should be taken with water along with a meal. If you have trouble swallowing the entire tablet, check with your doctor on alternate ways of taking it.
The dosage for the various indications is given below:
Nonvalvular Atrial Fibrillation:
For patients with Creatinine clearance (CrCl) greater than 50 mL/min: 20 mg orally, once daily with the evening meal
For patients with CrCl 15 to 50 mL/min: 15 mg orally, once daily with the evening meal. Avoid use in patients with CrCl less than 15 mL/min.
Prophylaxis of Deep Vein Thrombosis (DVT): :
10 mg orally, once daily with or without food.
Hepatic impairment (for nonvalvular AF and prophylaxis of DVT indications):
Avoid use in patients with moderate (Child-Pugh B) and severe (Child-Pugh C) hepatic impairment or with any degree of hepatic disease associated with coagulopathy.
Consult your doctor immediately if you happen to take more than the prescribed dose of Rpigat tablets (Rivaroxaban) since excessive intake of these tablets may put you at an increased risk of bleeding.
You should not stop taking these tablets unless instructed by your doctor to do so. Rpigat tablets (Rivaroxaban) are not recommended for children or adolescents.
Missed Dosage Instructions for Rpigat Tablets
If you miss a dose of Rpigat tablets (Rivaroxaban), take the prescribed quantity as soon as you remember. However, never take more than the prescribed dose in a day. You can continue taking your regular dose at the scheduled time the next day and thereafter. For instance, you have been prescribed one Rpigat 20mg tablet a day, but you forget to take it on a particular day.
You only remember the next day that you had missed a dose the previous day. In this scenario, do not try to make up for the missed dose by taking two Rpigat 20 mg tablets the next day. Stick to your regular daily dose of one Rpigat 20 mg tablet the next day and every day after that.
Contraindications
Rpigat tablets are contraindicated in patients with a hypersensitivity to Rivaroxaban or any inactive ingredient present in Rpigat tablets.
Rpigat tablets are also contraindicated in patients with active pathological bleeding. .
Storage Instructions for Rpigat tablets (Generic Rivaroxaban Tablets)
Rpigat tablets (Generic Rivaroxaban Tablets) should be stored at 25 degrees Celsius or room temperature. Excursions are permitted to (59°F to 86°F, 15°C to 30°C). Protect from light. Rpigat tablets should be kept out of the reach of children.
Warnings and Precautions to be taken when using Rpigat tablets (Generic Rivaroxaban Tablets)
Before using Rpigat tablets please inform your doctor about all the medicines that you take including no prescription medications, over the counter medicines and herbal remedies.
Haemorrhagic Risk:
As with other anticoagulants, patients taking Rpigat tablets (Generic Rivaroxaban Tablets) should be carefully observed for signs of bleeding. It is recommended to be used with caution in conditions with increased risk of haemorrhage. Rpigat administration should be stopped if severe haemorrhage occurs.
Kidney:
Please consult your doctor before taking Rpigat tablets (Rivaroxaban) if you suffer from severe kidney disease. This is because the condition of your kidney/s may not allow for the optimal functioning of Rpigat tablets. Severe kidney disease also puts you at a higher risk of bleeding.
High Blood Pressure:
Please consult your doctor before taking Rpigat tablets (Rivaroxaban) if you suffer from very high blood pressure, but you are not being medically treated for it. One of the consequences of high blood pressure can be an increased risk of bleeding.
Lungs:
If you have had bleeding in your lungs or suffer from a lung disease called bronchiectasis, please check with a doctor before taking Rpigat (Rivaroxaban). Bronchiectasis is a lung disease that leads to your bronchi widening and filling with pus.
Pregnancy-Related Hemorrhage:
Use Rpigat with caution in pregnant women due to the potential for obstetric hemorrhage and/or emergent delivery. In pregnant women, Rpigat should be used only if the potential benefit justifies the potential risk to the mother and fetus. Rpigat dosing in pregnancy has not been studied.
Prosthetic heart valves:
Rpigat use not recommended.
Increased Risk of Thrombosis in Patients with Triple Positive Antiphospholipid Syndrome:
Use of Rpigat tablets is not recommended.
Surgery:
If there is a surgery or another treatment planned to remove blood clots from your lungs, let your doctor know before taking Rpigat (Rivaroxaban) so that your doctor can decide whether to prescribe Rivaroxaban or go with another line of treatment.
Driving Or Using Machines
A common side effect of Rpigat (Rivaroxaban) is dizziness. Do not drive if you experience dizziness after taking Rpigat (Rivaroxaban).
Some people also complain of fainting as one of Rpigat’s side effects. If that is one of its side effects on you, stay away from operating machines.
Rivaroxaban and Alcohol
Abstain from drinking alcohol if you are taking Rpigat (Rivaroxaban).
Others
Please consult your doctor before taking Rpigat (Rivaroxaban) if you suffer from retinopathy, any diseases of the stomach or bowel that could lead to bleeding, or any other bleeding disorders.
Please consult your doctor before taking Rpigat (Rivaroxaban) if you have a prosthetic heart valve.
If you are already on anti-blood clotting medications such as Warfarin, Heparin, Dabigatran, or Apixaban, or are changing your anti-blood clotting treatment, please let your doctor know before taking Rpigat (Rivaroxaban).
Please also inform your doctor before taking Rpigat (Rivaroxaban) if you are suffering from a medical condition called antiphospholipid syndrome, so that your doctor can make an informed decision regarding your treatment. Antiphospholipid syndrome affects the immune system and results in an increased risk of blood clotting.
Side Effects of Rpigat Tablets (Rivaroxaban Tablets)
The most common Rivaroxaban (Rpigat tablets) side effect with an incidence rate of 5% or more in adult patients was bleeding.
The most common Rivaroxaban (Rpigat tablets) side effects with an incidence rate of 10% or greater in pediatric patients were bleeding, cough, vomiting, and gastroenteritis.
The side effects of taking Rpigat tablets (Rivaroxaban) may include:
- Excessive bleeding or bleeding for a longer duration of time (including blood in the urine or heavy menstrual bleeding)
- Bleeding from the skin or under the skin
- Coughing up blood
- Bruising
- Swelling of the limbs or unexplained swelling
- Breathlessness
- Abdominal pain, nausea, constipation, vomiting, diarrhoea
- Weakness, fatigue, dizziness, headache
- Fever
- Low blood pressure resulting in dizziness or fainting
- Rashes on the skin or other allergic reactions
- Increased heartbeat
- Dry mouth
Rpigat Tablets During Pregnancy
Rivaroxaban (Rpigat tablets) has been classified by the US FDA as Pregnancy Category C. There are no adequate or well-controlled studies of Rivaroxaban tablets in pregnant women, and dosing for pregnant women has not been established. Animal reproduction studies showed no increased risk of structural malformations, but increased post-implantation pregnancy loss occurred in rabbits.
Do not take Rpigat tablets (Rivaroxaban) if you are pregnant as it could be harmful for your baby. If you are already taking Rpigat tablets (Rivaroxaban) and there is a chance you may get pregnant, please ensure that you use a contraceptive during sexual intercourse. If you get pregnant while you are on Rpigat (Rivaroxaban), consult your doctor immediately.
Rivaroxaban (Rpigat tablets) should be used during pregnancy only if the potential benefit justifies the potential risk to mother and fetus.
Breastfeeding
It is not known if Rivaroxaban is excreted in human milk. Rivaroxaban and/or its metabolites were excreted into the milk of rats.
Do not take Rpigat (Rivaroxaban) if you are breastfeeding. Since many medicines are excreted in human milk , you may pass it on to the baby through breast milk, and that may be unsafe for the baby.
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