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Skelebenz Tablets – Product Information
Skelebenz (Cyclobenzaprine HCl) is a skeletal muscle relaxant which relieves muscle spasm of local origin and associated pain in acute musculoskeletal conditions without interfering with muscle function. Skelebenz Tablets for oral administration are supplied in 15 mg strengths.
Name of Drug
Skelebenz. This medication is also referred to as Cyclobenzaprine Tablets.
Manufacturer of Skelebenz Tablets (Cyclobenzaprine Tablets)
Sun Pharmaceutical Industries Ltd.
Active Pharmaceutical Ingredients
The active ingredient in Skelebenz Tablets is Cyclobenzaprine Hydrochloride. Cyclobenzaprine Hydrochloride (Cyclobenzaprine HCl) is a white, crystalline tricyclic amine salt.
What is Cyclobenzaprine Tablets (Skelebenz Tablets) Used For
Skelebenz (Cyclobenzaprine HCl) is used along with proper rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions. Improvement is manifested by relief of muscle spasm and its associated signs and symptoms, namely, pain, tenderness, and limitation of motion. Cyclobenzaprine Tablets should be used only for short periods (up to two or three weeks)
Skelebenz Tablets – Dosage
The recommended adult dose for most patients is one Skelebenz (Cyclobenzaprine Hydrochloride) 15 mg Tablet taken once daily. Some patients may require up to 30 mg/day. It is recommended that doses be taken at approximately the same time each day. Use of Cyclobenzaprine Tablets for periods longer than two or three weeks is not recommended.
Contraindications of Skelebenz Tablets
Skelebenz Tablets are contraindicated in patients with a history of hypersensitivity to Cyclobenzaprine Hydrochloride or any other ingredients of Skelebenz Tablets. It is also contraindicated in the following cases:
- Concomitant use of monoamine oxidase (MAO) inhibitors or within 14 days after their discontinuation.
- Hyperpyretic crisis seizures and deaths have occurred in patients receiving cyclobenzaprine (or structurally similar tricyclic antidepressants) concomitantly with MAO inhibitor medications.
- During the acute recovery phase of myocardial infarction, and in patients with arrhythmias, heart block conduction disturbances, or congestive heart failure.
Drug Class and Mechanism
Cyclobenzaprine acts primarily within the central nervous system at the brain stem as opposed to the spinal cord level, although an overlapping action on the latter may contribute to its overall skeletal muscle relaxant activity. Evidence suggests that the net effect of cyclobenzaprine is a reduction of tonic somatic motor activity, influencing both gamma and alpha motor systems.
If you miss a dose of Cyclobenzaprine Tablets, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your dose at thescheduled time. Do not double a dose to make up for a missed dose.
Storage Instructions for Cyclobenzaprine Tablets (Skelebenz)
Store Skelebenz Tablets between 59°F and 86°F (15°C and 30 °C) in well-closed containers.. Keep Cyclobenzaprine Tablets out of the reach of children and away from pets.
Warnings and Precautions when using Cyclobenzaprine Tablets
Before using Cyclobenzaprine Tablets (Skelebenz Tablets) please inform your doctor all the medicines that you take including no prescription medications, over the counter medicines and herbal remedies.Skelebenz is closely related to the tricyclic antidepressants, e.g., amitriptyline and imipramine. Short term studies have shown that at doses somewhat greater than those recommended for skeletal muscle spasm, some of the more serious central nervous system reactions noted with the tricyclic antidepressants have occurred.Tricyclic antidepressants have been reported to produce arrhythmias, sinus tachycardia, prolongation of the conduction time leading to myocardial infarction and stroke. Skelebenz may enhance the effects of alcohol, barbiturates, and other CNS depressants.
Use of Cyclobenzaprine Tablets (Skelebenz Tablets) is not recommended in subjects with mild, moderate or severe hepatic impairment. As a result of a 40% increase in cyclobenzaprine plasma levels and a 56% increase in plasma half life following administration of Skelebenz Tablets in elderly subjects as compared to young adults, use of Skelebenz is not recommended in elderly.
Skelebenz should be used with caution in patients with a history of urinary retention, angle-closure glaucoma, increased intraocular pressure, and in patients taking anticholinergic medication.
Possible Side Effects of Cyclobenzaprine Tablets (Skelebenz) Tablets
The most common side effects of Cyclobenzaprine Tablets (occurring in 3% or more patients) were dry mouth, dizziness, fatigue, somnolence, constipation Nausea and Dyspepsia. The most common adverse reactions reported most frequently in a postmarketing surveillance program were drowsiness, dry mouth, and dizziness. Side effects which were reported in 1% to 3% of the patients were: fatigue/tiredness, asthenia, nausea, constipation, dyspepsia, unpleasant taste, blurred vision, headache, nervousness, and confusion. The following adverse reactions have been reported in post-marketing experience or with an incidence of less than 1% of patients.
- Body as a Whole: Syncope; malaise.
- Cardiovascular: Tachycardia; arrhythmia; vasodilatation; palpitation; hypotension.
- Digestive: Vomiting; anorexia; diarrhea; gastrointestinal pain; gastritis; thirst; flatulence; edema of the tongue; abnormal liver function and rare reports of hepatitis, jaundice, and cholestasis.
- Hypersensitivity: Anaphylaxis; angioedema; pruritus; facial edema; urticaria; rash.
- Musculoskeletal: Local weakness.
- Nervous System and Psychiatric: Seizures, ataxia; vertigo; dysarthria; tremors; hypertonia; convulsions; muscle twitching; disorientation; insomnia; depressed mood; abnormal sensations; anxiety; agitation; psychosis, abnormal thinking and dreaming; hallucinations; excitement; paresthesia; diplopia.
- Skin: Sweating.
- Special Senses: Ageusia; tinnitus.
- Urogenital: Urinary frequency and/or retention.
Buy Skelebenz Tablets and Online at Cheap Price
You can buy Skelebenz Tablets (Cyclobenzaprine Tablets) at a cheap price online from the Swiss Pharmacy. It is available in pills of 15 mg. The 15 mg pills are priced at only $1.25 per unit, if you place an order for 180 pills.
This Product was added to our catalogue on Wednesday, 12. September 2012.
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