Generic Nitazoxanide Tablets (Nizonide Tablets) – Product Information
Generic Nitazoxanide tablets (Nizonide 500mg Tablets) are an antiprotozoal agent indicated for the treatment of infectious diarrhea caused by Giardia lamblia or Cryptosporidium parvum in patients 12 years of age and older.
Nizonide tablets are manufactured by Lupin limited, India, in the strength of 500 mg.
We also stock Forcan Tablets (Generic Fluconazole 150mg and 200 mg) which are used for treating and preventing certain yeast and fungal infections.
Name of Drug
Nizonide Tablets
Manufacturer of Nizonide Tablets (Generic Nitazoxanide Tablets)
Lupin Limited, India
Website: https://www.lupin.com/
Active Pharmaceutical Ingredient
The active pharmaceutical ingredients contained in Nizonide tablets is Nitazoxanide. Each Nizonide tablet contains 500 mg of Nitazoxanide.
Mechanism of Action
The antiprotozoal activity of Nitazoxanide is believed to be due to interference with the
pyruvate:Ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction which is
essential to anaerobic energy metabolism.
Studies have shown that the PFOR enzyme from Giardia lamblia directly reduces nitazoxanide by transfer of electrons in the absence of ferredoxin. The DNA-derived PFOR protein sequence of Cryptosporidium parvum appears to be similar to that of Giardia lamblia.
Interference with the PFOR enzyme-dependent electron transfer reaction may not be the only pathway by
which Nitazoxanide exhibits antiprotozoal activity.
